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1

Dendritic cell-targeting DNA-based mucosal adjuvants for the development of mucosal vaccines

Kataoka, Kosuke, Fujihashi, Kohtaro

Journal:

Expert Review of Vaccines

Year:

2009

Language:

english

File:

PDF, 1.62 MB

english, 2009

2

Mucosal vaccination and immune responses in the elderly

Kohtaro Fujihashi, Toshiya Koga, Jerry R. McGhee

Journal:

Year:

2000

Language:

english

File:

PDF, 127 KB

english, 2000

3

Inside the Mucosal Immune System

McGhee, Jerry R., Fujihashi, Kohtaro

Journal:

Year:

2012

Language:

english

File:

PDF, 586 KB

english, 2012

4

Mucosal Vaccines || Mucosal Vaccines for Aged: Challenges and Struggles in Immunosenescence

Fujihashi, Kohtaro

Year:

2020

Language:

english

File:

PDF, 1.40 MB

english, 2020

5

Novel vaccine development strategies for inducing mucosal immunity

Fukuyama, Yoshiko, Tokuhara, Daisuke, Kataoka, Kosuke, Gilbert, Rebekah S, McGhee, Jerry R, Yuki, Yoshikazu, Kiyono, Hiroshi, Fujihashi, Kohtaro

Journal:

Expert Review of Vaccines

Year:

2012

Language:

english

File:

PDF, 487 KB

english, 2012

6

Human Nasopharyngeal-Associated Lymphoreticular Tissues: Functional Analysis of Subepithelial and Intraepithelial B and T Cells from Adenoids and Tonsils

Prosper N. Boyaka, Peter F. Wright, Mariarosaria Marinaro, Hiroshi Kiyono, Joyce E. Johnson, Ricardo A. Gonzales, Mine R. Ikizler, Jay A. Werkhaven, Raymond J. Jackson, Kohtaro Fujihashi, Simonetta Di

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 1.43 MB

english, 2000

7

Production of a recombinant hybrid molecule of cholera toxin-B-subunit and proteolipid-protein-peptide for the treatment of experimental encephalomyelitis

Yoshikazu Yuki, Youngjin Byun, Mitsugu Fujita, Wakako Izutani, Toru Suzuki, Shigezo Udaka, Kohtaro Fujihashi, Jerry R. McGhee, Hiroshi Kiyono

Journal:

Biotechnology and Bioengineering

Year:

2001

Language:

english

File:

PDF, 103 KB

english, 2001

8

Intestinal intraepithelial lymphocyte T cells are resistant to Ipr gene-induced T cell abnormalities

Wilhelm K. Aicher, Kohtaro Fujihashi, Takashi Taguchi, Jerry R. McGhee, Masafumi Yamamoto, John H. Eldridge, Steffen Gay, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1992

Language:

english

File:

PDF, 937 KB

english, 1992

9

The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes

Kenneth W. Beagley, Kohtaro Fujihashi, C. Allen Black, Anand S. Lagoo, Masafumi Yamamoto, Jerry R. McGhee, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 481 KB

english, 1993

10

Cytokine synthesis and apoptosis by intestinal intraepithelial lymphocytes: Signaling of high density αβ T cell receptor+ and γδ T cell receptor+ T cells via T cell receptor-CD3 complex results in interferon-γ and interleukin-5 production, while low density T cells undergo DNA fragmentation

Masafumi Yamamoto, Kohtaro Fujihashi, Masahiko Amano, Jerry R. McGhee, Kenneth W. Beagley, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 683 KB

english, 1994

11

Characterization of cytokine-producing cells in mucosal effector sites: CD3+ T cells of Th1 and Th2 type in salivary gland-associated tissues

Takachika Hiroi, Kohtaro Fujihashi, Jerry R. McGhee, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1994

Language:

english

File:

PDF, 753 KB

english, 1994

12

Polarized Th2 cytokine expression by both mucosal γδ and αβ T cells

Takachika Hiroi, Kohtaro Fujihashi, Jerry R. McGhee, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 1.05 MB

english, 1995

13

An interleukin-7 internet for intestinal intraepithelial T cell development: Knockout of ligand or receptor reveal differences in the immunodeficient state

Kohtaro Fujihashi, Jerry R. McGhee, Masafumi Yamamoto, Jacques J. Peschon, Hiroshi Kiyono

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 716 KB

english, 1997

14

Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-κB translocation

Yuki I. Kawamura, Rei Kawashima, Yuko Shirai, Rie Kato, Takashi Hamabata, Masafumi Yamamoto, Koichi Furukawa, Kohtaro Fujihashi, Jerry R. McGhee, Hideo Hayashi, Taeko Dohi

Journal:

European Journal of Immunology

Year:

2003

Language:

english

File:

PDF, 272 KB

english, 2003

15

Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Aβ1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease

Hong-Duck Kim, Kazuki Tahara, J. Adam Maxwell, Robert Lalonde, Tatsuya Fukuiwa, Kohtaro Fujihashi, Kent R. Van Kampen, Fan-Kun Kong, De-chu C. Tang, Ken-ichiro Fukuchi

Journal:

The Journal of Gene Medicine

Year:

2007

Language:

english

File:

PDF, 394 KB

english, 2007

16

Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus

Etsuhisa Takahashi, Kosuke Kataoka, Kazuyuki Fujii, Junji Chida, Dai Mizuno, Makoto Fukui, Hiro-O Ito, Kohtaro Fujihashi, Hiroshi Kido

Journal:

Microbes and Infection

Year:

2010

Language:

english

File:

PDF, 220 KB

english, 2010

17

A T cell/B cell/epithelial cell internet for mucosal inflammation and immunity

Kohtaro Fujihashi, Mi-Na Kweon, Hiroshi Kiyono, John L. VanCott, Frederick W. Ginkel, Masafumi Yamamoto, Jerry R. McGhee

Journal:

Seminars in Immunopathology

Year:

1997

Language:

english

File:

PDF, 1.16 MB

english, 1997

18

Mucosal regulatory cells in the gastrointestinal tract and periodontium

Ichiro Takahashi, Kohtaro Fujihashi, Hiroshi Kiyono

Journal:

Periodontology 2000

Year:

2010

Language:

english

File:

PDF, 600 KB

english, 2010

19

Characterization of T and B Cells Isolated from Mucosa-Associated Tissues of the Rhesus Macaque

Dong-Won Kang, Susumu Ohkawa, Simonetta Difabio, Katherine W. Merrill, Kohtaro Fujihashi, Masafumi Yamamoto, Christopher J. Miller, Marta Marthas, Jerry R. McGhee, John H. Eldridge, Michael Murphey-Co

Journal:

Cellular Immunology

Year:

1993

File:

PDF, 577 KB

1993

20

Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses

Jerry R. McGhee, Kohtaro Fujihashi, Kenneth W. Beagley, Hiroshi Kiyono

Journal:

Immunologic Research

Year:

1991

Language:

english

File:

PDF, 322 KB

english, 1991

21

Regulatory functions for murine intraepithelial lymphocytes in mucosal responses

Hiroshi Kiyono, Kohtaro Fujihashi, Takashi Taguchi, Wilhelm K. Aicher, Jerry R. McGhee

Journal:

Immunologic Research

Year:

1991

Language:

english

File:

PDF, 510 KB

english, 1991

22

Recombinant human interleukin 6 (rhIL-6) promotes the terminal differentiation of in vivo-activated human B cells into antibody-secreting cells

Cummins Lue, Hiroshi Kiyono, Jerry R. McGhee, Kohtaro Fujihashi, Tadamitsu Kishimoto, Toshio Hirano, Jiri Mestecky

Journal:

Cellular Immunology

Year:

1991

Language:

english

File:

PDF, 645 KB

english, 1991

23

Luminometry: a novel bioluminescent immunoassay enhances the quantitation of mucosal and systemic antibody responses

Raymond J. Jackson, Kohtaro Fujihashi, Hiroshi Kiyono, Jerry R. McGhee

Journal:

Journal of Immunological Methods

Year:

1996

Language:

english

File:

PDF, 818 KB

english, 1996

24

Mucosal immunity and tolerance in the elderly

Kohtaro Fujihashi, Jerry R. McGhee

Journal:

Mechanisms of Ageing and Development

Year:

2004

Language:

english

File:

PDF, 307 KB

english, 2004

25

A Novel Alkaline Phosphatase-Based Isolation Method Allows Characterization of Intraepithelial Lymphocytes from Villi Tip and Crypt Regions of Murine Small Intestine

Shigetada Kawabata, Prosper N Boyaka, Michel Coste, Kohtaro Fujihashi, Shigeyuki Hamada, Jerry R McGhee, Hiroshi Kiyono

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 482 KB

english, 1997

26

Cytokine-specific ELISPOT assay single cell analysis of IL-2, IL-4 and IL-6 producing cells

Kohtaro Fujihashi, Jerry R. McGhee, Kenneth W. Beagley, David T. McPherson, Sylvia A. McPherson, Chun-Ming Huang, Hiroshi Kiyono

Journal:

Journal of Immunological Methods

Year:

1993

Language:

english

File:

PDF, 1.57 MB

english, 1993

27

Mucosal immunosenescence: new developments and vaccines to control infectious diseases

Kohtaro Fujihashi, Hiroshi Kiyono

Journal:

Trends in Immunology

Year:

2009

Language:

english

File:

PDF, 731 KB

english, 2009

28

A single intranasal immunization with inactivated influenza virus and α-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system

Hyun-Jun Youn, Sung-Youl Ko, Kyoo-A. Lee, Hyun-Jeong Ko, Yoon-Sook Lee, Kohtaro Fujihashi, Prosper N. Boyaka, Sang-Hee Kim, Taisuke Horimoto, Mi-Na Kweon, Chang-Yuil Kang

Journal:

Year:

2007

Language:

english

File:

PDF, 899 KB

english, 2007

29

Long- and short-time immunological memory in different strains of mice given nasally an adjuvant-combined nasal influenza vaccine

Hideki Asanuma, Kohtaro Fujihashi, Takashi Miyakoshi, Tomoki Yoshikawa, Yoko Fujita-Yamaguchi, Naoya Kojima, Munehiro Nakata, Yujiro Suzuki, Shin-ichi Tamura, Takeshi Kurata, Tetsutaro Sata

Journal:

Year:

2007

Language:

english

File:

PDF, 495 KB

english, 2007

30

A combination of Flt3 ligand cDNA and CpG ODN as nasal adjuvant elicits NALT dendritic cells for prolonged mucosal immunity

Tatsuya Fukuiwa, Shinichi Sekine, Ryoki Kobayashi, Hideaki Suzuki, Kosuke Kataoka, Rebekah S. Gilbert, Yuichi Kurono, Prosper N. Boyaka, Arthur M. Krieg, Jerry R. McGhee, Kohtaro Fujihashi

Journal:

Year:

2008

Language:

english

File:

PDF, 2.27 MB

english, 2008

31

Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategy

Naoto Yoshino, Kohtaro Fujihashi, Yukari Hagiwara, Hiroyuki Kanno, Kiyomi Takahashi, Ryoki Kobayashi, Noriyuki Inaba, Masatoshi Noda, Shigehiro Sato

Journal:

Year:

2009

Language:

english

File:

PDF, 1.03 MB

english, 2009

32

Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity

Yoshikazu Yuki, Daisuke Tokuhara, Tomonori Nochi, Hiroshi Yasuda, Mio Mejima, Shiho Kurokawa, Yuko Takahashi, Nobuhiro Kataoka, Ushio Nakanishi, Yukari Hagiwara, Kohtaro Fujihashi, Fumio Takaiwa, Hiro

Journal:

Year:

2009

Language:

english

File:

PDF, 613 KB

english, 2009

33

Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination

Tselmeg Baatarjav, Kosuke Kataoka, Rebekah S. Gilbert, Yutaka Terao, Makoto Fukui, Masaki Goto, Shigetada Kawabata, Masafumi Yamamoto, Kohtaro Fujihashi, Hiro-O Ito

Journal:

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

34

A novel combined adjuvant for nasal delivery elicits mucosal immunity to influenza in aging

Hideki Asanuma, Normaiza Binti Zamri, Shinichi Sekine, Yoshiko Fukuyama, Daisuke Tokuhara, Rebekah S. Gilbert, Tatsuya Fukuiwa, Keiko Fujihashi, Tetsutaro Sata, Masato Tashiro, Kohtaro Fujihashi

Journal:

Year:

2012

Language:

english

File:

PDF, 910 KB

english, 2012

35

Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection

Seol Hee Hong, Young-Ho Byun, Chung Truong Nguyen, Soo Young Kim, Baik Lin Seong, Songyong Park, Gyu-Jin Woo, Yeup Yoon, Jeong Tae Koh, Kohtaro Fujihashi, Joon Haeng Rhee, Shee Eun Lee

Journal:

Year:

2012

Language:

english

File:

PDF, 952 KB

english, 2012

36

Pathological Role of Large Intestinal IL-12p40 for the Induction of Th2-Type Allergic Diarrhea

Ayako Hino, Mi-Na Kweon, Kohtaro Fujihashi, Jerry R. McGhee, Hiroshi Kiyono

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 605 KB

english, 2004

37

CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis

Taeko Dohi, Kohtaro Fujihashi, Toshiya Koga, Yuri Etani, Naoto Yoshino, Yuki I. Kawamura, Jerry R. McGhee

Journal:

The American Journal of Pathology

Year:

2004

Language:

english

File:

PDF, 1.36 MB

english, 2004

38

Effects of intranasal immunization on protective immunity against otitis media

Yuichi Kurono, Masashi Suzuki, Goro Mogi, Masafumi Yamamoto, Kohtaro Fujihashi, Jerry R McGhee, Hiroshi Kiyono

Journal:

International Journal of Pediatric Otorhinolaryngology

Year:

1999

Language:

english

File:

PDF, 60 KB

english, 1999

39

Nasal immunization with E. coli verotoxin 1 (VT1)-B subunit and a nontoxic mutant of cholera toxin elicits serum neutralizing antibodies

Youngjin Byun, Mari Ohmura, Kohtaro Fujihashi, Shingo Yamamoto, Jerry R. McGhee, Shigezo Udaka, Hiroshi Kiyono, Yoshifumi Takeda, Takao Kohsaka, Yoshikazu Yuki

Journal:

Year:

2001

Language:

english

File:

PDF, 449 KB

english, 2001

40

Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin

Mari Ohmura, Masafumi Yamamoto, Hiroshi Kiyono, Kohtaro Fujihashi, Yoshifumi Takeda, Jerry R McGhee

Journal:

Year:

2001

Language:

english

File:

PDF, 119 KB

english, 2001

41

A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants

Kohtaro Fujihashi, Toshiya Koga, Frederik W. van Ginkel, Yukari Hagiwara, Jerry R. McGhee

Journal:

Year:

2002

Language:

english

File:

PDF, 161 KB

english, 2002

42

Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics

Shigetada Kawabata, Prosper N. Boyaka, Michel Coste, Kohtaro Fujihashi, Masafumi Yamamoto, Jerry R. McGhee, Hiroshi Kiyono

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 134 KB

english, 1998

43

Mucosal immunity: Regulation by helper T cells and a novel method for detection

Raymond J. Jackson, Mariarosaria Marinaro, John L. VanCott, Masafumi Yamamoto, Nobuo Okahashi, Kohtaro Fujihashi, Hiroshi Kiyono, Steven N. Chatfield, Jerry R. McGhee

Journal:

Journal of Biotechnology

Year:

1996

Language:

english

File:

PDF, 754 KB

english, 1996

44

Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin

Jiangchun Xu-Amano, Raymond J. Jackson, Kohtaro Fujihashi, Hiroshi Kiyono, Herman F. Staats, Jerry R. McGhee

Journal:

Year:

1994

Language:

english

File:

PDF, 1.15 MB

english, 1994

45

Cholera toxin adjuvanticity is dependent upon Gm1-mediated NF-κB translocation and activation of dendritic cells

Yuki I. Kawamura, Yuko Shirai, Takashi Hamabata, Masafumi Yamamoto, Koichi Furukawa, Kohtaro Fujihashi, McGhee R. Jerry, Taeko Dohi

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 180 KB

english, 2003

46

A revisit of the hapten-induced colitis model: Adoptive T cell transfer studies

Yuri Etani, Jerry R. McGhee, Kohtaro Fujihashi

Journal:

Gastroenterology

Year:

2001

Language:

english

File:

PDF, 186 KB

english, 2001

47

Mice Deficient in Th1- and Th2-Type Cytokines Develop Distinct Forms of Hapten-Induced Colitis

Taeko Dohi*, †, Kohtaro Fujihashi§, Hiroshi Kiyono§, ∥, Charles O. Elson¶, Jerry R. McGhee*

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 630 KB

english, 2000

48

T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell–deficient mice

Taeko Dohi, Kohtaro Fujihashi, Toshiya Koga, Yuko Shirai, Yuki I. Kawamura, Chieko Ejima, Rie Kato, Kiyoshi Saitoh, Jerry R. McGhee

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 596 KB

english, 2003

49

Ovalbumin-Protein σ1 M-Cell Targeting Facilitates Oral Tolerance With Reduction of Antigen-Specific CD4+ T Cells

Hideaki Suzuki, Shinichi Sekine, Kosuke Kataoka, David W. Pascual, Massimo Maddaloni, Ryoki Kobayashi, Keiko Fujihashi, Haruo Kozono, Jerry R. McGhee, Kohtaro Fujihashi

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 945 KB

english, 2008

50

The Role of Th1 and Th2 Cells for Mucosal IgA Responses

MASAFUMI YAMAMOTO, JOHN L. VANCOTT, NOBUO OKAHASHI, MARIAROSARIA MARINARO, HIROSHI KIYONO, KOHTARO FUJIHASHI, RAYMOND J. JACKSON, STEVEN N. CHATFIELD, HORST BLUETHMANN, JERRY R. McGHEE

Journal:

Annals of the New York Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 505 KB

english, 1996

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